Personally I expect self-driving cars to drive a great deal more conservatively than humans as a result, and I think self-driving cars are going to end up demanding a lot more space and buffer on the freeways. And if they don't at first, one day you'll way up and they suddenly all will, because somebody won some lawsuit and a software update was pushed overnight to double the buffers.
And we haven't even considered networking. When the cars are all talking to each and routed together then it's fundamentally a single machine.
The laws and systems will evolve with capabilities rather than getting stuck on supporting the earliest generation of self driving vehicles and norms.
I think other drivers will adapt to this and start taking advantage. Think of what happens when you leave a legal following distance in front of you now, in traffic. Now imagine an autonomous car in the same situation. It would probably end up stopped.
There's still a chance an automated car encounters something that couldn't be spotted / reacted to. For example a deer/kangaroo/whatever jumping right in front of it. If the cars keep their distance, only the first one crashes. If they form a minimum-spacing train, the only message they can send to the following ones is "you're screwed now".
I don't have much experience with deer behaviour, but kangaroos will happily jump right into anything moving. They will even hit the side of your car sometimes (which they should've obviously seen coming)