Of course there are a few simple compounds which are edible, but most artificial additives are extracted and processed from grown inputs, and this is susceptible to unexpected health problems as happened with exposure to trans fats for decades - now banned.
> we can certainly create a synthetic smoothie with the necessities of life
That is a low bar - being capable at any cost to synthesis a smoothie with 'the necessities of life' including growth? good health? You didnt even reference that.