That is true - alcohol is both nmda antagonist (the stumbly ataxia) and gaba agonist (effect on anxiety.) GHB IMO is not nearly as gnarly of a substance as alcohol because it sort of has a ceiling but withdrawal from any gabaergic is uncomfortable and potentially life threatening and nmda agonists are not, there are a lot of causes of bladder damage especially from ketamine, drowning, falling off buildings, loss of jobs, friends, family. Despite it's rather low physical harm profile (aside from the bladder damage) it's incredibly addictive and many people go wayyyyy wayyyyyyyy too far. I have lived it, and I've seen it. It has a very dark side.

I know the IV user in this film (they call him Chris on camera). This user is atypical but there are many people with extensive bladder damage and negative social effects. You'll have to take my word for it. I'm sure there is more research from china especially as it's very common drug used there. Police note (anecdotally) the typical user in north america has changed to middle aged and affluent as the price of street ketamine has gone up from maybe $25/g to +$90 https://www.snagfilms.com/films/title/drugs_inc_ketamine

I believe in its power as an antidepressant. I'm just concerned about the effects a bit. It will fuel research - it seems it's not ketamine but metabolites and effects on ganglial growth that spur the sudden changes to a depressed mind. And a new objective view on life and reality.