"I'm intrigued by this study but also suspicious... It seems a lot of "illicit" substances are being touted as possible depression aides, such as shrooms and MDMA."

I've done MDMA multiple times. I'm over 35. I did it recreationally with my spouse. I know the recreational doses and the theraputic doses are the same.

And boy, did it solve some stuff in my brain. All positive. I'm better equipped to deal with anxiety and depression than I was before. I was.. OK. With myself, with things, and so on. The next day and week or so after, it felt like by brain had been rinsed off, massaged, and gently put back in place. Now, this slowly lessened, but I was able to deal with stuff. It is really hard to explain: Like finally getting glasses and being amazed with how clear things were. I can only imagine how this would be in a clinical setting, with someone guiding your brain to deal with things you needed to deal with. Also, I found I like myself. That's not nothing.

Now, I've never done Ketamine, but I imagine results are similarly helpful for folks this is a good match with especially when you are in a clinical setting.