I personally refuse to call anyone a male or female if they were not born with the right parts. This is a mental issue.
What is wrong with a man accepting his biological sex and identifying as female, for example? I think the issue is that said man wants people to call him "she" so he can feel his womanhood complete, something he can never achieve because he's still genetically male and his femininity can only imitate that of a genetic female.
He is Paul, born male and identified as female. She is Susan, born female and identified as gay male. Simple.
This has very little to do with actual science, and more to do with hatred of Trump.