* Its load times are ridiculously high compared to Chrome
* Sometimes when my netflix window freezes up, it takes down the whole browser with it (though I know its running in a separate process)
* Opening downthemall's manager window makes for whole browser unresponsive for a few seconds
* Detaching a tab reloads it (unlike chrome or ie9)
The only reason I still use firefox is because of firebug and downthemall.