By nature, we understand the "what' and "why' of each supercomputer component, as they have been built by us from the bottom up. We are orders of magnitude from understanding each component of the cell. When you get into the weeds, the methods used to dissect these processes are generally slow, indirectly and subject to relatively subjective interpretation and poor reproducablility (vs chemistry or physics). Don't get me wrong, I love this stuff and was drawn to a molecular biology career by curiosity around the wide grey line that separates what is living and what is a bag of molecules, but having spend many years at the bench still think that the Biology part of Synthetic Biology will be the bottleneck rather than the bioinformatics/synthetic methods, tho improvements in this stuff will greatly help.