The atomic bomb is one obvious example of a technology that seems to be inherently bad not only for humanity, but for biological life itself.
You could argue that the problem of the bomb is more-so a problem of finding a bad technical solution to the problem of war, but it's quite difficult to think of a beneficial application of the atomic bomb, and thus, very difficult to justify its invention from a moral/valued standpoint.
I think it's also a problem that we seem to treat technological progress as a glorified end for humanity—we find it very difficult, for whatever reason (perhaps economic as you point out) to have the courage to admit when something shouldn't be invented, even if it presumably can be. I think part of this stems from the co-opting of science by technology, and science's silly claim to be "value-free" and neutral—which has had some disastrous consequences. If I'm engaged in a value-free enterprise, I have no reason to stop and wonder what devastation or havoc my creation might one day wreak, I'm doing it, after all, in the name of science, or progress, of unreflective pursuit of an end I can't forsee.