It would be like saying that something can’t work because it’s a placebo - even if all they’re getting is a sugar pill, if the symptoms went away, that’s not really something that you can argue with.
I put audiophiles on the same level as sommeliers. The best wine is the one that tastes best to the drinker. You can haul out your GCMS to test the wine and your ABX testing software to test the audio and tell someone their subjective experience is Wrong, but this misses the point. We’re not talking about medical efficacy here, we’re talking about artwork.