The best advice of the video is to have a strong vision of the future. How will the world be fundamentally different in 10 years compared to how it is today. Think about that change, and then build a company that will be well positioned with the new change. The stronger your vision, and the more accurate it is, the better your chance of success is.
In 10 years there will be a dozen 1 trillion dollar companies. The number of $100B companies is going to explode as well. More and more commerce is happening on the internet which scales much easier than brick and motor commerce. More and more goods purchased are entirely virtual, and have huge margins. More and more value is in software, which can be copied and used without practical limits. If your goal is to start a company that grows to $100B there has never been a better time to do that than right now.