Out of the 2000 or so startups that deserve some type of funding[1], the chance that you will pick a $1B unicorn is about 0.2%.
Additionally, the chance that you will choose the next Airbnb or Stripe is closer to 0.002%.
For comparison, you could turn $150,000 into $4,500,000 with about a 3% chance if you find a vegas table willing to service this bet size (which they have done in the past).
[1]a16z said this recently