My goal right now is to do just that. Get a remote job and move away from the high CoL area I am in. I personally like living in more rural areas. My spouse, not so much, but she may end up with a great job at a university in a small-town.
I really think as a knowledge worker there is no point to being limited to where you live for employment.
But remote companies seem to be very picky about who they hire. I have not had much luck. Local places won't stop spamming me though.