I read comments here on this thread and people are amazed that they will become irrelevant to next-gen super-humans. As if this the only possible outcome. What I see is that people are blind to something that will come back to bite really hard.
How can you know that the result is an advancement and not a regression?
Others are blind to the fact that history was not only roses and fun and people justified a lot of atrocities with "progress".
In the future, genetic enhancements will be available in a regulated competitive marketplace, and the ones that have unforseen bad consequences will fall out of favour.
Capitalism doesn't either. Capitalism answers to profits and not necessarily to _everybody_'s profits.