1. Rearrange a few select keys - Backspace goes on Capslock, Ctrl goes on Alt, Alt goes on Windows key, Windows key goes on Ctrl.
Doing this allows me to hit Ctrl with my thumb instead of my pinky with way less wrist rotation. Alt can then still be hit with my thumb with a short reach. Backspace doesn't require completely extending my whole right hand.
2. Switching to the Dvorak keyboard layout. While claims that Dvorak is faster than Qwerty are dubious, I think it's fairly clear that there is less finger movement with Dvorak. My fingers stay much more on the home row.
3. Using Vim. The above combined with remapping Escape to something not in the far upper left corner means I do very little weird hand contortions at all when coding. But, with Ctrl on Alt, any IDE requires much less wrist movement.
Yes my keyboard is completely weird and my editor incomprehensible to anyone else, but my hands are super comfy. For an 80/20 optimization, just rearranging Backspace, Ctrl, and Alt might save you the worst of wrist damage. On Windows a simple AutoHotKey script can do it.