not really. Neurons fire in the absense of any stimulus at some base noise floor rate, so there’s always a little bit of uncertainty. They don’t really act like logic units, close up.
Why would this be an argument against getting data of an individual neuron? We would obviously just have some filtering applied to it to attempt to remove the noise, in the simplest case even just a noise gate adjusted to that default rate. It would still provide information from individual neurons.
you can absolutely get data from an individual neuron. What data you get is not a truth table.