the main things, i think, necessary to make somewhere a great location for a startup are public infrastructure and talent, i dont know anything about naples, but i wonder first and foremost how good the local talent is, and second how well it can attract talent. is the airport accessible to direct flights to say sfo, etc. are there incentives to place datacenters, although not a hard requirement because of aws, gcp ovmh, but it helps, i imagine it’s a volcanic zone, so probably not. look at all the great startup cities in the world and you’ll find strong universities that have great talent, the univiersities help to lure the talent, the companies help to keep them.
obviously this has lots of ties with government where they could make things easier.
from the first picture, it looks like a great place to live on the mediterannean, but the crime and filth sounds bad.