The most successful people I know in business have no formal education, no career. My super smart friends with PhDs and advanced degrees can't touch a business with a 100 meters stick. They work in places like Academia, constantly talking bad about it.
They will be paralyzed at taking risks, handling this much responsibility over other people. The constant fight, people looking at you for guidance and having to decide with incomplete information,people not paying you, your salaries, your taxes... The anxiety they would face is too much for them.
With all the money in the world, with all the connections it takes an entire emotional reprogramming of your mind to be able to handle this.
I regularly see people with 100.000, 200.000 euros in the bank telling me they can't create the business they always dreamed about, if only they had enough money...the reality is that they are in doubt, insecure about risking their own money but somewhat they expect someone else to risk their own money trusting them when they can't even trust themselves.