I believe we have had a few efforts at direct cellular level and genetic intervention - things like treating immune cells to teach them to attack cancer cell. These efforts have often been disappointing. And in general, genetic engineering has faced a lot of road blocks.

The problem one faces is one is using debugging-techniques on a lasagna of only "code-like" commands that no resemblance to the code-divisions or processes of human-generated code.

IE, Nearly all "genetic engineering" is cut-and-paste changes hoping that such operations can give one-for-one changes in the attributes of organisms. Sometimes this works but it seems like it have inherent limitations. It seems to me progress will require understanding what the genetic code does and that's going to require different progress than what we have now.