Could you elaborate a bit, specially about melatonin ?
Personally I've only taken melatonin when I most needed it, and then gave up on it. You should try giving it up, too, unless you really can't do without it.
You should check the vitamin D level, too, whenever you do your next blood test.
As for curcumin, the Longvida formula seems to be most effective. I can't say I've noticed any effects from it myself, but I haven't taken it daily, and I've also read that you need to take curcumin for 2+ weeks to see the effects.
https://www.turmericforhealth.com/curcumin-benefits-and-dosa...
[1] https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-079X...
https://nutritionfacts.org/video/turmeric-curcumin-plants-vs...
I find him convincing in general in terms of diet etc and he has a lot of other good content.
My opinion on melatonin comes from him too, but I can't find the relevant material.