I've used TCL in production for 15 years. The only thing to really worry about is a consistent policy on language usage.
Keeping to the base features of the language and extensions in tcllib/tclx is a pretty solid recipe.
That said here are things I advise.
* No upvar/uplevel. Use a namespace. * Use apply wisely. * No ad-hoc (say swig inline wrappers) extensions without deep review. * If you are writing a front end in tk - think twice. * If you are doing OOP with TCL choose wisely.