The advantages are that it can have extremely dense chip to chip connections, as much as ~10,000X as dense as TSVs (literally) and no ESD diode capacitance (can be as much as ~50fF!!).
The disadvantages are that copper interconnects melt above ~400 degrees celsius, and we are around ~1200 degrees celsius to make transistors. There are a few ways around this but they usually result in crummier transistors.