The rest of your comment sounds a bit misinformed to me. You seem to have decided that prototypical inheritance is somehow inherently worse than classical inheritance, but don't mention why that would be. I have found very little practical difference between the classes in JS and other languages in everyday use, and can't quite imagine what the problems with it might be.
Furthermore, ES6 (ES2015) is not a "transpiled language". I think it's obvious that if you take a very new language, say, ES2018 and want to run it on your toaster that doesn't have support for such new languages, you are going to have to do some kind of precompilation step. That is true for ES2018 today and it will be true for ES2019 next year and for ES2020 the year after that.
ES2015, however, has been around for several years. All the modern browsers (that is, all major browsers except IE) support it already. Node 10 even supports the new module loading syntax (behind a flag), or you can use a very lightweight transformer like esm[1] for older Node versions.
And if you do end up using and having problems with, say, Babel, it would be more constructive to give concrete examples of the issues you've had. I personally have never faced a syntax problem where the issue would've been due to a bug in Babel instead of just my incorrect understanding of the language feature.