It can't be overstated how confining it is when anything you'd like to do or see involves logistical wrangling to work out when exactly you need to be there, how long you'll be there, when you need to be picked up, etc. I've lost count of the number of times I've just decided to not bother with all that and just stay home, which makes for a pretty depressing existence after a while.
Things like uber can help, but you're still placing your trust in someone you've never met to be able to get you there, and more importantly, to be able to get you back home. Not to mention having to do an upfront value analysis to determine if the trip is worth it, and for disabled people this can be a tough call given the difficulties with employment and income in general.