Some thoughts (in no particular order):
- some have, and have responded, but we aren't looking for them in the right place and in the right way
- humans have only been able to actively send information into space since only about the 1950s (radio waves), and physics dictates that locations 80 light years away are just now starting to see that, provided they are looking in the right location and in the right way (and that they are technologically advanced enough to do so.
- It could be that a sufficiently advanced civilization no longer has the capability to receive and transmit long-wave radio communications. Just like many computers now don't have any way to read a floppy disk, or if someone were trying to communicate via smoke signals, you'd be hard pressed to find anyone who could understand it.
- Space is so large that if a civilization several hundred light years away (an insignificant fraction of the size of our one galaxy, actually) sent us a message that we received and responded to, it's possible they could have collapsed by the time they receive our response. The converse is also true, they could have 'seen' us and sent a message, and we could collapse before we had a chance to receive it and respond.