The counter-argument to many "design flaws" is, as a sibling comment mentioned, they may be "artifacts of the complexity of reality," especially
constraints due to the fact that living things are built up from single cells and need to be functional during the growth process, as opposed to being pieced together like a robot from existing materials.
IANABiologist, but I think I've heard that the giraffe nerve has to grow that way due to the way it starts growing, or that there is a rare mutation that doesn't actually grow that way, but it doesn't get selected for, presumably due to some other side effect.
There are also counter-arguments related to constraints regarding human eyes... Octopus eyes are supposed to be superior, not backwards with no blind spot, but I think human eyes can see way farther outside of water.
(I welcome informed corrections to any ignorance I may be spouting).
Essentially, there's a lot of nuance between "maybe it's smart and we don't know it" and "these are definitely very serious design flaws" - whether you think things were intelligently designed, evolved, or intelligently designed via evolution, it seems reasonable to think there may be at least some reasons that a lot of things were selected to be the way they are, and not what may at first glance seem obviously better, at least if you haven't considered all the relevant constraints.