But I'm concerned about the subtler, not-obviously-harmful-but-not-necessarily-desirable ways in which they permanently alter the brain. Slate Star Codex has a few recent articles that are worth considering:
http://slatestarcodex.com/2018/06/06/hppd-and-the-specter-of...
http://slatestarcodex.com/2016/04/28/why-were-early-psychede...