I think it is all about resources you can bring on the table. Bigger resources means bigger leverage. I think you need to bring business skills AND some money, the more money you have, the better.

I heard that the historical CEO of Nintendo, Hiroshi Yamauchi, didn't know how to use Nintendo gaming machines. He almost never played any of his games. But he has the money and business acumen to hire guys like Gunpei Yokoi (engineer) and Shigeru Miyamoto(game designer).

I also heard that Intuit was started by Scott Cook, a marketing geek, who brought business skills and enough money to lure Tom Proulx. Scott Cook met Tom Proulx when he came to the Stanford campus, looking for a programmer.

So, if you have vision, business skills and are able to raise some money, it is possible.