Consider the almost exclusive dataset they have moated "everyone" else out of, and the long line of disingenuous/unethical business practices. The privacy considerations are the proverbial top of the iceberg.
Altered Carbon also uses goverment as the primary seat of power. United Nations Envoy Corps are primarily a reskinning of Dune's Sardaukar, the powerful super soldiers that enforce the rule of law out of fear. There are very powerful corporations, especially those discussed in the first book, but their power is again through the influence of government, and goverment has the authority to act independently.
This is in comparison to a true mega-corp like Final Fantasy 7's Shinra Corporation, where all power exists within the company. Shinra can destroy 1/8th of the capitol city with no repercussions, and there is no significant economic activity outside of the company.
Yours is a terrifying endgame, but it feels (to me) quite far removed from what we should look out for before it's too late.
I'm specifically concerned about their approaches and attitudes on AI and Life Sciences.