1. The elephant in the room, Apple, is highly non compliant with web standards (iOS Safari lacks js web workers, webgl 2, WebRTC data channel, and many many others)
2. The roadmap of webassembly is merely the start of glaring unsolved problems
3. GPU compute will play an increasingly important role in the future, given the advent of AI, complex cryptography, video, image,... The web and browser have outdated and insufficient support for the same
4. Access to sensors and peripherals is abysmal. WebUsb is a step in the right direction, but much needs to happen there