But there's a significant difference in the sense that drones are the only way these strikes are conducted. Manned strikes would be more risky, since they expose a pilot, and less practical because manned aircraft can't be "parked" over a target for anywhere near as long as a drone. And whatever the legality of the situation, the political reality is that manned strikes look substantially more like an act of war.
So the difference is that many of these strikes wouldn't happen without drones. It's not about how the bomb is delivered, it's about whether we're assassinating people without a declaration of war in the first place.