I'm not worried about Facebook or Google, because they spend millions on lawyers, but this seems potentially terrifying for startups. Any U.S. state can make a law making some part of their service illegal, and someone can sue the startup even if their company wasn't operating in that state. A startup would need to know and obey all laws in all states, and have enough money to fight legal cases.
I wonder if the golden age of startups is over. It would be impossible to navigate through these regulations if you just wanted to create a side project for fun.