Interesting, early on with a 4K monitor on a Mac I was having trouble with kernel panics I wonder if this was the cause.
I thought it was just a combination of low-end MBP (cheapest 13" available) and crappy 4K monitor (Sceptre U274K). Are you saying that there is an actual problem with macOS High Sierra that is causing my lag? I've already changed DP cables and that didn't help at all. :(