No commute, homemade lunch, more family time...?
You bet it's healthier. Except perhaps slightly increased exposure to the three germ incubating kids under 5 that live here, but there's not much I can do about that now apparently.
EDIT: I think kids-flu is hard to avoid at that age, home office or not :P
You could homeschool them.
for me the best situation has always been being a few minutes walking distance from the office. work stays at work, home stays at home, no commute, no bullshit.