Super handy when you want multiple cursors to line up at the start of every line (by default vscode will wrap the cursor around to the end of the longer lines if you try to move around with the arrow keys).
There's about 20 other extensions I routinely use, which I documented at https://nickjanetakis.com/blog/switching-to-vscode-from-subl....
Additionally, there is a case where if you don't select the last line until the end, you end up in a state where the last cursor is already at the beginning. If you press "Home" now, you end up having that last cursor at the beginning of the line - and the other ones at the indentation level (see https://github.com/Microsoft/vscode/issues/14919#issuecommen...)
(Disclaimer: Author of the mentioned plugin, so I am heavily biased against my own workflow and saving-keypresses-obsession :P)
Pressing home doesn't always put you at the true beginning of the line. It will put you at the first non-whitespace character.
It only took using a keyboard for about 22 years to learn pressing home more than once has benefits.
Thanks!