What about people who moved from European countries, did you enjoy it? Just something I have considered, but wasn't sure. Like how does the infrastructure compare, such as public transport?
Disadvantages include having an older population, being small compared to New York, having less of a startup culture than SF, being very expensive, having many hurdles to get a residency permit for an American, and various innocuous cultural differences that simply take getting used to.
That said, I love it there and am heading back.
Good luck with your startup!
It really depends on the bus line how frequent they come. The 9 and 47 come right by my house and come every 10-15 minutes if not less. They are both heavily travelled lines. The 12 also comes by and it's less travelled and probably averages one bus every 25-30 minutes or so.
There is also a bus schedule that they "try" to adhere too. That's true for almost every city, so you can just look at the lines that run by where you are going to be and see how often they come.
Finally, all of the SF MUNI Buses and trains are gps equipped so you can check a pretty accurate estimate of when they will be at your stop online or through various smartphone apps. Very handy for preventing you from having to wait at a bus stop for more than a few minutes.