> Can one not understand something about how cultures work without knowing how brains work?
Yes, you can, but that's psychology or sociology, not neuroscience. The goal was to understand brain, and be able to replicate it or modify it. Understanding just the behaviour is like understanding that pressing "fire" will shoot in Space Invaders. It's something, but you don't need to dissect a CPU to know that, and it doesn't move you closer to creating your own CPU or modifying this one.
> the only worthwhile understanding of phenomena is from the bottom
That's misrepresentation of my point. I wrote that in the CPU example neuroscience tools failed because of missing the abstraction levels between transistors and behaviours.
> there is some true level of description at which something must be understood
There is optimal level of description, yes. And notation makes a huge difference.