Problems with multithreading and "perceived immutability" are two more things that can largely be ruled out with a clear dataflow architecture. For example, I try to not have "cycles" such that a function call overwrites a memory location that was a (pointer) argument to the caller. I don't think that should happen - where did the called function get the pointer from without the caller knowing?

An architecture with global data tables instead of OOP helps here, because it has much lower need for pointer arguments of unclear origin. I also agree very much with your approach "handles instead of pointers" (if by handles you mean integer array indices). Indices for example trivially survive reallocation of a dynamically growable array.