If you tailor your resume you are wasting your time, period.
If you're "just another developer" applying to a "just a developer" req, then yes there's probably no reason to tweak. For anything else, you should absolutely be reconfiguring your resume to highlight your relevant skills.
Tailoring, in this case, meant relatively minor tweaks - if it was a more engineering role I'd highlight those skills and contributions whereas with the more data science-y roles I'd highlight more relevant aspects. I think it's very arrogant to think that a single resume is appropriate for every job application.