My one issue with Firefox right now is CPU use. On my iMac or on desktop it doesn't truly matter. But on a MBP no matter how many tabs I have or what I'm doing the fans never turn on with Chrome. On Firefox they turn on regularly.
I've tested while looking at the activity monitor a bit. Loading random sites like HN show Firefox spiking to 80-90% CPU while Chrome spikes to 20-30%.