While 34k is and probably was very low, Fort Wayne Indiana is one of the lowest CoL cities in US. I wish they would tech take more seriously there, but they're in for an uphill battle if they do with Detroit, Indianapolis and Chicago competing for talent in the close proximity.
I think there is a real opportunity for state side digital nomads who want to live cheap while starting a business. Places like fort Wayne Indiana give them access to a lively downtown, cheap housing and access to 1st tier cities in a few hours drive. Source - I grew up there.