Maybe this isn't the best advice but I think we're capable of doing pretty extraordinary things when you're thrown into the deep end. You'd be surprised at how things start to work out once you're 100% out of your comfort zone.
I'm not saying quit your job immediately while still in debt or whatever. I just think that if you're debt free and have a few months of savings you could at least give starting your own business a fair shot without a safety net. If things don't look like they are going to work out, you could always find some type of job to pay the bills.