I general, from what I've gathered, we have been replacing substances that accumulates in nature with substances that breaks down over time. So for instance, we still do allow ozone but also watch the levels to ensure they aren't too high.
I know there are issues with a lot of medication as it goes out in the sewage and there's still a big question mark on the safety of some modern materials such as nano particles. However, the overall the feeling I get is that the awareness of the dangers with allowing use of poisonous substances is a lot higher today than before. I'm interested in hearing about the exceptions.