I believe there have been some studies that show that artificial sweeteners affect your insulin response to real sugar, but I think it's far from settled science.
https://www.cambridge.org/core/journals/british-journal-of-n...
The tricky thing is some artificial sweeteners spiked mine, while others triggered hers.
So it isn't enough to say "artificial sweeteners do | do not", you'd need to test your own reactions via blood glucose testing. So many pin pricks. Neat data though.