From the custom skeletal hand mouse cursor, to the crossbones used as borders for some images [0], to the mouseovers on some of the initials where the letter is photoshopped out to show the background [1], to the fact that the site still has a guestbook [2]... there's a great character to the site that makes it enjoyable to interact with. Much more engaging than the overpolished style of so much online nowadays.
I also thought it was interesting to note the practice of almost-copies of certain woodcut illustrations over the centuries [0]. In our era of trivial lossless copying of digital data, it's easy to forget how much had to be done by hand in the past.
[0] http://www.dodedans.com/Eholbein26.htm [1] http://www.dodedans.com/Eholbeina.htm [2] http://www.dodedans.com/Ebook01.php