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Depends on how complicated the app is.

Most of the times a good old non-SPA with NodeJS / Express / Some ORM with vanilla JS / Handlebars and SASS will do the job without having a huge technical debt.

If on the other hand the requirements are to have a more complicated SPA, I would go with React / Redux and a NodeJS / Express / ORM for the API. Hosting the front-end on an S3 and the backend on a Digital Ocean Droplet.

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NodeJS + TypeScript works wonderfully. Nunchuck templates (Jinja2 inspired).

And we use Angular on the front end.

And I'd recommend GraphQL, takes a lot of worry about API design and wiring off your shoulders.

Let me second Handlebars. There is nothing simpler than a plain old REST Api on the back end + Bootstrap + Handlebars + JQuery mostly for Ajax calls

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