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1. Resources 2. Talent 3. Money 4. Travel Costs / Accessibility

These ideas all come to mind on why you would want to be in a major hub. That said I believe a start up can start anywhere but needs to be prepared to relocate should the needs of the business demand that they do so.

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That said I believe a start up can start anywhere but needs to be prepared to relocate should the needs of the business demand that they do so.

Yeah, moving away from major hubs can be a good way to save money.

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