It doesn't suffer GNOME disease, it has mail, contacts, calendar, RSS, and if you want, a browser. It's reasonably stable and robust.
My principle preference remains console tools -- Mutt, lbdb, and a mash of other tools, or the Emacs world -- but that's not what the general end-user probably wants.
I've also found Sylpheed is an exceptionally good "just email and contacts" application. Fast, light, and simple.
Before I switched away from Gnome I had Evolution set up. It was slow, you couldn't make more than one operation at a time and notifications worked randomly. Even if you had new email, Evolution sometimes decided not to notify you for days. Reminders and synchronization of calendar and tasks were even worse.