The Clathrate gun hypothesis and the thawing of the Arctic ecosystem are two of the "Four Horsemen of the Apocalypse" that the US government investigates. These are possible scenarios for abrupt climate change (aka tipping points). The other two involve antarctic ice sheet instability and megadroughts in North America.
http://newscenter.lbl.gov/2008/09/17/impacts-on-the-threshol...