I've done this in the past. I had 3 false displays set up using virtual desktop and HDMI dummies. When I got used to it, it was very pleasant. One day I sat down, did some working, and then watched some shows. I actually fell asleep with the headset on once. It was, to say the least, confusing when I first woke up in outer space.

It was very pleasant. I wish I had a Rift to try it with, the lenses on the Vive are rough, with my only experience before the Vive being the DK2. http://www.roadtovr.com/wp-content/uploads/2015/05/wearality... This effect was highly noticeable for me.

Never had an issue with my mouse or KB. I went onto the app where you were in a living room, with other people in the online room around you, and you each had your desktop in your lap. It was pretty cool to play Overwatch and this guy comment when something sick happened.

I don't believe VR belongs in the gaming scene. Business / EDU all the way. I'd be curious if there's any plans to research trying to get kids to develop synesthesia using VR.

I do also sit at a desk chair. I ended up stopping using it a lot unless I'm trying to drown out everything around me because I am very paranoid if I can't see all exits/entrances to a room with my back to the wall. Still probably the most eye-opening experience for VR for me. Being able to come into my office, with only my desk in a part of the room, sit there with my KB&M and virtual displays, and then move around my room separately for things like Tilt Brush would be amazing.