Absolutely -- IMHO for mid-distance (200 mi to 500 mi or so) trips, Amtrak is a really underrated option. I travel semi-often from Pittsburgh to NYC (450 mi) and choose train over flights because it's actually not that much slower (consider to/from airport, security, and (de)boarding, as you say) and it's much more comfortable: I can walk up and down the whole train, with no fasten-seatbelt sign to stop me; there's a cafe car; I have about 2 feet of legroom; there is reliable AC power and functional wifi. I just make it a work-from-train day and all's well.